Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effect of gamma interferon on lung function of mustard gas exposed patients, after 15 years

(2006) Effect of gamma interferon on lung function of mustard gas exposed patients, after 15 years. Pulmonary Pharmacology & Therapeutics. pp. 148-153. ISSN 1094-5539

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Background: Bronchiolitis has been known to be among the main the pathological features of lung lesions in Mustard Gas (MG) exposed patients. The purpose of this research was to evaluate the efficacy of interferon gamma-1b on the lung function in MG exposed patients with bronchiolitis. Method: Thirty-six bronchiolitis patients, whose lung lesion had been diagnosed through High Resolution Computerized Tomography (HRCT) of the chest and also pathological study, were divided into two 18-member case and control groups. Both groups were receiving their conventional treatment (inhaled Felixotide and Servent). The case group were treated for 6 months with a combination of 200 mu g of interferon gamma-1b (given three times per week subcutaneously) plus 7.5 mg of prednisolone (given once a day), while the control group received their previous conventional medications. Lung function was measured at base line and after 1, 3 and 6 months of treatment. Results: In case and control groups, Forced Expiratory Volume in first second (FEV1) did not have statistical differences at the base line (49.3 +/- 2.9 and 48.7 +/- 4. 1, respectively = 0.6), whereas a significant increase was seen in the case group (66.3 +/- 5.4) compared control group (57.3 +/- 8.6) at the subsequent months (P = 0.001 for the difference between the groups). Similar pattern of increase was observed in Forced Vital Capacity (FVC). Conclusion: The findings of this study indicate that a 6-month treatment with interferon gamma-1b plus a low-dose prednisolone is associated with an improvement in the lung function in mustard-gas exposed patients with bronchiolitis. (c) 2005 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: transforming growth factor-beta(1) necrosis-factor-alpha gene-expression tgf-beta bronchiolitis obliterans mouse model growth-factor-beta-1 fibrosis collagen inhibition Pharmacology & Pharmacy Respiratory System
Page Range: pp. 148-153
Journal or Publication Title: Pulmonary Pharmacology & Therapeutics
Journal Index: ISI
Volume: 19
Number: 2
Identification Number:
ISSN: 1094-5539
Depositing User: مهندس مهدی شریفی

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