Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

(2020) Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy. ACS Combinatorial Science. pp. 669-700. ISSN 2156-8952

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Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and bioavailability of natural compounds have limited their efficacy in cancer therapy. To circumvent this hurdle, nanocarriers have been designed to improve the antitumor activity of the aforementioned compounds. Nevertheless, cancer treatment is still a challenge, demanding novel strategies. It is well-known that a combination of natural products and gene therapy is advantageous over monotherapy. Delivery of multiple therapeutic agents/small interfering RNA (siRNA) as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells. In the present review, codelivery of natural compounds/siRNA using nanovehicles are highlighted to provide a backdrop for future research.

Item Type: Article
Keywords: anticancer therapy chemotherapy co-delivery platforms nanocarriers natural products small interfering RNA low-density-lipoprotein mesoporous silica nanoparticles chitosan-based nanoparticles epithelial-mesenchymal transition enhanced anticancer efficacy modified cationic liposomes solid lipid nanoparticles cell-cycle redistribution anti-survivin sirna nano-graphene oxide Chemistry Pharmacology & Pharmacy
Page Range: pp. 669-700
Journal or Publication Title: ACS Combinatorial Science
Journal Index: ISI
Volume: 22
Number: 12
Identification Number:
ISSN: 2156-8952
Depositing User: مهندس مهدی شریفی

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