Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The what and who of dietary lignans in human health: Special focus on prooxidant and antioxidant effects

(2020) The what and who of dietary lignans in human health: Special focus on prooxidant and antioxidant effects. Trends in Food Science & Technology. pp. 382-390. ISSN 0924-2244

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Background: Lignans are large group of polyphenols that are formed by the coupling of two coniferyl alcohol residues. Based on their origin, lignans are broadly grouped into plant lignans such as isolariciresinol, secoisolariciresinol diglucoside, lariciresinol, and matairesinol; and mammalian lignans such as enterodiol and enterolactone. Based on the oxidation level of the lignan skeleton, they are also categorized into numerous groups such as dibenzylfuran, dibenzylbutyrolactol, dihydroxybenzylbutane, arylnaphtalene and aryltetraline lactone derivatives. Depending on structural type and concentration, numerous dietary lignans have been shown to possess biological activities including protective effect against diseases such as hormone-dependent tumors and cardiovascular diseases. Also, they display antioxidant properties in tissues and organs including the liver and the brain, lignans are found in most fiber-rich seeds such as sesame and pumpkin, and grains including barley, wheat, oats and rye. Scope and approach: This paper focus on the metabolism in humans, and recent studies on the antioxidant and possible prooxidant effects of lignans at three levels: in vitro, in vivo in animals and clinical studies. Key Findings and Conclusions: Most of the studies investigating the antioxidant effect of lignans were in vitro and animal models and only five clinical trials were found; one evaluating the effect of enterolactone on low-density lipoprotein (LDL) peroxidation and four investigating the effects of plant lignans including flaxseed lignan components, secoisolariciresinol and sesamin on lipid peroxidation. So, lignans seem to be a valuable source for identifying new molecules for preventing various diseases especially cardiovascular disorders. Since most of studies are preclinical, however, further clinical trials are required to achieve more conclusive results.

Item Type: Article
Keywords: Prooxidant Antioxidant Enterolignan Oxidative stress Free radicals Medicinal herb Herbal medicine Phytochemical induced oxidative stress in-vitro secoisolariciresinol-diglycoside nordihydroguaiaretic acid carbon-tetrachloride flaxseed lignan protects injury apoptosis sesamin Food Science & Technology
Page Range: pp. 382-390
Journal or Publication Title: Trends in Food Science & Technology
Journal Index: ISI
Volume: 106
Identification Number:
ISSN: 0924-2244
Depositing User: مهندس مهدی شریفی

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