Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Linagliptin electrochemical sensor based on carbon nitride-beta-cyclodextrin nanocomposite as a modifier

(2020) Linagliptin electrochemical sensor based on carbon nitride-beta-cyclodextrin nanocomposite as a modifier. Journal of Electroanalytical Chemistry. p. 9. ISSN 1572-6657

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Linagliptin (LGP) is a novel hypoglycemic drug that belongs to the dipeptidyl-peptidase-4 inhibitor class that was approved in 2011 for the treatment of type 2 diabetes. Today, the integration of different materials and electrochemistry has opened a new horizon to develop highly selective, sensitive, rapid and reliable techniques to detect and quantify such vital analytes. The purpose of this article is to develop an improved carbon paste electrode (CPE) with graphitic carbon nitride/beta-cyclodextrin nanocomposite (gCN-beta CD/CPE) as an electrochemical sensor for the measurement of LGP. For this purpose, gCN was synthesized from melamine and mixed with beta CD to obtain a nanocomposite for the chemical modification of CPE. The influence of modifier on the selectivity, sensitivity, response and lifetime of the CPE was investigated. The results show that the developed LGP electrochemical determination method has a broad range of linearity from 0.01 to 50 mu M (R-2 > 0.986) based on differential pulse voltammetry (DPV) responses. The detection limit of the method was 3 nM and the probable interference influence on the analytical signal of LGP was insignificant. The improved electrode was successfully used to measure LGP in the blood serum sample with a satisfactory relative recovery (>95.6).

Item Type: Article
Keywords: Linagliptin Carbon paste electrode beta-cyclodextrin Graphitic carbon nitride molecular imprinting polymer paste electrode voltammetric determination nanotubes recognition photocatalyst dopamine behavior surface drug Chemistry Electrochemistry
Page Range: p. 9
Journal or Publication Title: Journal of Electroanalytical Chemistry
Journal Index: ISI
Volume: 876
Identification Number:
ISSN: 1572-6657
Depositing User: مهندس مهدی شریفی

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