Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Pregnancy Outcomes of Wives of Chemical and Non-Chemical Weapons Exposed Veterans in Ahvaz, Iran: A Retrospective Cohort Study

(2020) Pregnancy Outcomes of Wives of Chemical and Non-Chemical Weapons Exposed Veterans in Ahvaz, Iran: A Retrospective Cohort Study. Prehospital and Disaster Medicine. pp. 477-481. ISSN 1049-023X

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Background: Sulphur mustard (HD) is a lipophilic caustic alkylating vesicant (blister agent) that has mutagenic and carcinogenic effects. Among the studied perturbations are long-term genitourinary (GU) and fertility effects. Approximately 50,000 Iranian soldiers and civilians were exposed to HD during the Iraq-Iran war (1980-1989). This study questioned the wives of Iraq-Iran war veterans to determine the effects of male HD-exposure on pregnancy complications, adverse pregnancy outcomes, and secondary infertility. Methods: A retrospective, survey-based cohort study was conducted of wives of Iranian military veterans that survived HD-associated injuries while serving in Ahvaz, Iran during the Iraq-Iran war (1980-1989), as compared to non-exposed veterans serving concomitantly. Patients were identified from a database of injured veterans maintained by the Foundation of Martyrs and Veterans Affairs (Iran) via a systematic random sampling method utilizing a random number table. Using a validated questionnaire, collected data included: demographics; type and severity of chemical injury; spouse's obstetric history (pregnancy number, duration, complications, and outcomes before and after spouse's chemical injury); and secondary infertility. Results: An increase in spontaneous abortion (P = .03), congenital anomalies (P < .0001), and secondary infertility (P = .003) were observed. These findings were greatest amongst those with HD injuries affecting >50 body surface area. No difference in stillbirth, premature birth, or low birth weight was observed. Conclusion: Exposure to HD in combat may have long-lasting fertility effects on soldiers and their spouses, including spontaneous abortion, congenital anomalies, and secondary infertility. Further investigation is needed into the long-term effects of HD exposure as well as methods to better protect soldiers.

Item Type: Article
Keywords: chemical warfare disaster infertility mustard gas pregnancy outcome congenital-malformations perinatal-mortality sulfur mustard preterm labor risk-factors prevalence infertility birth yazd Emergency Medicine
Page Range: pp. 477-481
Journal or Publication Title: Prehospital and Disaster Medicine
Journal Index: ISI
Volume: 35
Number: 5
Identification Number:
ISSN: 1049-023X
Depositing User: مهندس مهدی شریفی

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