Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Biologically-synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications

(2020) Biologically-synthesised ZnO/CuO/Ag nanocomposite using propolis extract and coated on the gauze for wound healing applications. Iet Nanobiotechnology. pp. 548-554. ISSN 1751-8741

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Biologicallysynthesised ZnOCuOAg nanocomposite using propolis extract and coated on the gauze for wound healing applications.pdf

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Wound healing has long been recognised as a major clinical challenge for which stablishing more effective wound therapies is necessary. The generation of metallic nanocomposites using biological compounds is emerging as a new promising strategy for this purpose. In this study, four metallic nanoparticles (NPs) with propolis extract (Ext) and one without propolis including ZnO/Ext, ZnO/Ag/Ext, ZnO/CuO/Ext, ZnO/Ag/CuO/Ext and ZnO/W were prepared by microwave method and assessed for their wound healing activity on excision experimental model of wounds in rats. The developed nanocomposites have been characterised by physico-chemical methods such as X-ray diffraction, scanning electron microscopy, diffuse reflectance UV-vis spectroscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and Brunauer-Emmett-Teller analyses. The wounded animals treated with the NPs/Ext in five groups for 18 days. Every 6 days, for measuring wound closure rate, three samples of each group were examined for histopathological analysis. The prepared tissue sections were investigated by haematoxylin and Eosin stainings for the formation of epidermis, dermis and muscular and Masson's trichrome staining for the formation of collagen fibres. These findings toughly support the probability of using this new ZnO/Ag/Ext materials dressing for a wound care performance with significant effect compared to other NPs.

Item Type: Article
Keywords: nanomedicine X-ray diffraction II-VI semiconductors visible spectra ultraviolet spectra nanocomposites biomedical materials proteins wounds nanoparticles scanning electron microscopy nanofabrication skin zinc compounds silver antibacterial activity Fourier transform infrared spectra copper compounds molecular biophysics propolis wound healing applications effective wound metallic nanocomposites biological compounds metallic nanoparticles microwave method wound healing activity physico-chemical methods Fourier transform infrared spectroscopy diffuse reflectance UV-vis spectroscopy Brunauer-Emmett-Teller analyses wounded animals wound closure rate wound care performance histopathological analysis scanning electron microscopy X-ray diffraction thermogravimetric analysis haematoxylin Eosin stainings Masson trichrome epidermis muscular trichrome collagen fibres time 18 0 d time 6 0 d ZnO-CuO-Ag silver nanoparticles green synthesis leaf extract antibacterial copper zno hydrogel zinc model Biochemistry & Molecular Biology Science & Technology - Other Topics
Page Range: pp. 548-554
Journal or Publication Title: Iet Nanobiotechnology
Journal Index: ISI
Volume: 14
Number: 7
Identification Number:
ISSN: 1751-8741
Depositing User: مهندس مهدی شریفی

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