Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Designing a multi-epitope vaccine against blood-stage of Plasmodium falciparum by in silico approaches

(2020) Designing a multi-epitope vaccine against blood-stage of Plasmodium falciparum by in silico approaches. Journal of Molecular Graphics & Modelling. p. 12. ISSN 1093-3263

Full text not available from this repository.

Official URL:


Plasmodium falciparum causes the most severe form of malaria disease and is the major cause of infection-related mortalities in the world. Due to increasing in P. falciparum resistance to the first-line antimalarial drugs, an effective vaccine for the control and elimination of malaria infection is urgent. Because the pathogenesis of malaria disease results from blood-stage infection, and all of the symptoms and clinical illness of malaria occur during this stage, there is a strong rationale to develop vaccine against this stage. In the present study, different structural-vaccinology and immuno informatics tools were applied to design an effective antibody-inducing multi-epitope vaccine against the blood-stage of P. falciparum. The designed multi-epitope vaccine was composed of three main parts including B cell epitopes, T helper (Th) cell epitopes, and two adjuvant motives (HP91 and RS09), which were linked to each other via proper linkers. B cell and T cell epitopes were derived from four protective antigens expressed on the surface of merozoites, which are critical to invade the erythrocytes. HP91 and RS09 adjuvants and Th cell epitopes were used to induce, enhance and direct the best form of humoral immune-response against P. falciparum surface merozoite antigens. The vaccine construct was modeled, and after model quality evaluation and refinement by different software, the high-quality 3D-structure model of the vaccine was achieved. Analysis of immunological and physicochemical features of the vaccine showed acceptable results. We believe that this multi-epitope vaccine can be effective for preventing malaria disease caused by P. falciparum. (C) 2020 Elsevier Inc. All rights reserved.

Item Type: Article
Keywords: Multi-epitope vaccine Malaria Plasmodium falciparum merozoite Blood stage Bioinformatics Structural vaccinology naturally acquired antibodies merozoite surface protein-1 inhibitory antibodies hmgb1-derived peptide malaria invasion antigen prediction cells immunogenicity Biochemistry & Molecular Biology Computer Science Crystallography Mathematical & Computational Biology
Page Range: p. 12
Journal or Publication Title: Journal of Molecular Graphics & Modelling
Journal Index: ISI
Volume: 99
Identification Number:
ISSN: 1093-3263
Depositing User: مهندس مهدی شریفی

Actions (login required)

View Item View Item