Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

A longitudinal analysis of anesthesia data for cataract surgery: selection of working correlation structure

(2020) A longitudinal analysis of anesthesia data for cataract surgery: selection of working correlation structure. Ain Shams Journal of Anesthesiology. p. 6. ISSN 1687-7934

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Background Cataract surgery is most commonly done under local anesthesia with anesthesia and sedation controlled. Anesthetic depth and awareness monitoring during surgery frequently lead to irregular-timed observations. Inappropriate choice of working correlation structure in generalized estimating equations (GEE) may lead to inefficient estimation of parameters. The aim of this study was to apply the two new criteria to the anesthesia data for cataract surgery, to select and compare different candidates for working structure. Methods:In this randomized controlled trial, anesthesia depth and hemodynamic changes were considered to be the primary outcome. The first group received propofol at a dose of 50-75 mu g/kg/min and the second group received 1 isoflurane. We developed a GEE regression model based on several candidates for the working correlation framework and then evaluated it according to CEBIC (Constraint Empirical Bayesian Information Criterion) and CEAIC (Constraint Empirical Akaike Information Criterion) criteria. Data analysis was performed using the R software 3.6.1. Results: The mean age of the propofol group was 67.46 years (SD = 12.46 years) and 64.53 years for the isoflurane group (SD = 13.77 years). The mean BIS in isoflurane was higher among all time points than the propofol group, but only the difference between the two groups was statistically significant in 3 min after surgery (P = 0.04). On the basis of the CEAIC and CEBIC criteria, an independent working correlation was the best structure for the BIS outcome. In addition, the best structure was the unstructured correlation for HR. The MAP (mean arterial pressure) parameter estimate results revealed that the AR (1) structure was a good choice. Conclusion: In comparison to CIC and QIC, two CEAIC and CEBIC criteria have chosen a different structure for the working correlation between repeated measurements of anesthetic indices obtained during cataract surgery.

Item Type: Article
Keywords: Working correlation structure Longitudinal data Propofol Isoflurane Cataract Anesthesia generalized estimating equations administered propofol sedation elderly-patients prevalence adjunct care Anesthesiology
Page Range: p. 6
Journal or Publication Title: Ain Shams Journal of Anesthesiology
Journal Index: ISI
Volume: 12
Number: 1
Identification Number:
ISSN: 1687-7934
Depositing User: مهندس مهدی شریفی

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