Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Minocyclineattenuates testicular damages in a rat model of ischaemia/reperfusion (I/R) injury

(2020) Minocyclineattenuates testicular damages in a rat model of ischaemia/reperfusion (I/R) injury. Andrologia. p. 10. ISSN 0303-4569

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Testicular torsion is a serious urological disease leading to testicular damage. This study aimed to assess the effect ofminocyclineon testicular ischaemia/reperfusion (I/R) injury caused by testicular torsion/detorsion. Male adult Wistar rats (n = 32) were assigned into four groups of sham, I/R, I/R + minocyclineandminocycline. I/R injury was induced by two sets of surgical operations, including the rotation of the left testis (720 degrees, counterclockwise), followed by detorsion after 4 hr. The administration ofminocyclinewas carried out 30 min before detorsion and then continued for 8 weeks. At the end of the 8th week, rats were killed and sampling was done. Johnson's score, the height of seminiferous tubule epithelium, the mean seminiferous tubule diameter, as well as biochemical parameters, SOD, GPx and CAT, were significantly enhanced in the I/R + minocyclinegroup compared with the I/R group. The administration ofminocyclineled to a marked decrease in expression levels of Caspase-3, Bax, IL-1 beta and TNF-alpha genes, and a remarkable increase in expression levels of Bcl-2, 3 beta-HSD and 17 beta-HSD3 genes compared with the I/R group. Administration ofminocyclinecould also reduce the rate of germ cell apoptosis (TUNEL staining). Hence,minocyclinewas useful in the management of testicular torsion/detorsion.

Item Type: Article
Keywords: ischaemia reperfusion Minocycline oxidative stress apoptosis testicle tumor-necrosis-factor germ-cell apoptosis oxidative stress factor-alpha torsion inflammation steroidogenesis suppression activation pathway Endocrinology & Metabolism
Page Range: p. 10
Journal or Publication Title: Andrologia
Journal Index: ISI
Volume: 52
Number: 9
Identification Number:
ISSN: 0303-4569
Depositing User: مهندس مهدی شریفی

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