Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The current markers of cancer stem cell in oral cancers

(2020) The current markers of cancer stem cell in oral cancers. Life Sciences. p. 13. ISSN 0024-3205

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Head and neck cancer (HNC) constitute 5 of all reported cancers. Among all, the oral cavity cancer is the most frequent type of HNC which accounts for over half of HNC cases. Mouth cancer ranks the sixth leading cause of cancer-related mortality. Generally, conventional chemotherapy has shown success at decreasing relapse and metastasis rates and improves the overall prognosis. Recently, target therapy and targeted drug delivery systems have been introduced as promising treatments. The elimination of efficiency of current therapeutic strategies due to the spared cancer stem cells that cause chemotherapy resistance, relapse and metastasis. Inefficiency methodologies in the elimination of all cancer cells in the body are a major problem that remained to be resolved before to confront the new cancer therapies. Many studies imply to cancer stem cell markers as important agents for targeted anti-cancer as well as improving chemotherapy efficiencies. The potentials of targeted cancer therapy led us to search for novel markers in the mouth cancer stem cells especially in rare cancers. The aimed of this research was, first a comprehensive critical review of the previous studies on the markers of cancer stem cells in oral cancers including oral squamous cell carcinoma, salivary gland cancers, and to highlight the most common cancer stem cell markers which have potential to be exploited as indicators for the preneoplastic lesion malignancy, oral cancer progression, and/or treatment prognosis.

Item Type: Article
Keywords: Cancer stem cells Oral squamous cell carcinoma Oral cavity Sternness markers Adenoid cystic carcinoma Salivary gland cancers Mucoepidermoid carcinoma adenoid cystic carcinoma aldehyde dehydrogenase-activity prognostic-significance high expression poor-prognosis c-met predicts prognosis cd133 expression potential marker sox2 expression Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: p. 13
Journal or Publication Title: Life Sciences
Journal Index: ISI
Volume: 249
Identification Number:
ISSN: 0024-3205
Depositing User: مهندس مهدی شریفی

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