Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Bacterial infections in acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis

(2020) Bacterial infections in acute exacerbation of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Infection. pp. 19-35. ISSN 0300-8126

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Objective Due to the importance of Chronic obstructive pulmonary disease (COPD) as the fourth cause of mortality worldwide and the lack of studies evaluating the prevalence of bacterial infections in disease exacerbation, this systematic review and meta-analysis was performed to determine the prevalence rate of bacterial infections in COPD patients. Methods PubMed, ISI Web of Science, and Scopus databases were systematically searched for population-based prevalence studies (1980-2018). MeSH terms for "Bacterial infections" and "AECOPD" were used as search keywords. The selected studies were filtered according to the inclusion and exclusion criteria. Fixed and random-effects models were used for estimation of summary effect sizes. Between-study heterogeneity, as well as publication bias, were calculated. Results Finally, 118 out of 31,440 studies were selected. The overall estimation of the prevalence of bacterial infection was 49.59 95% confidence interval (CI) 0.4418-0.55. The heterogeneity in estimating the pooled prevalence of bacterial infections was shown in the studies (Cochran Q test: 6615, P < 0.0001, I-2 = 98.23%). In addition, S. pneumoniae, H. influenzae, M. catarrhalis, A. baumannii, P. aeruginosa, and S. aureus were the most prevalent reported bacteria. Conclusions Our results as the first meta-analysis for the issue demonstrated that bacterial infections are an important risk factor for AECOPD. Further studies must be performed for understanding the exact role of bacterial agents in AECOPD and help physicians for more applicable preventive and therapeutic measurements.

Item Type: Article
Keywords: AECOPD Bacterial infections Meta-analysis Systematic review mycoplasma-pneumoniae infection c-reactive protein polymerase-chain-reaction haemophilus-influenzae airway inflammation copd patients streptococcus-pneumoniae serological evidence chlamydophila-pneumoniae bacteriological etiology Infectious Diseases
Page Range: pp. 19-35
Journal or Publication Title: Infection
Journal Index: ISI
Volume: 48
Number: 1
Identification Number:
ISSN: 0300-8126
Depositing User: مهندس مهدی شریفی

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