Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Metabolic profiling of seminal plasma from teratozoospermia patients

(2020) Metabolic profiling of seminal plasma from teratozoospermia patients. J Pharm Biomed Anal. p. 5. ISSN 0731-7085

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Teratozoospermia is one of conditions that can cause male infertility. The mechanism of teratozoospermia remains unclear. The knowledge of the metabolites in human seminal plasma (HSP) is meaningful for the pathological study of teratozoospermia. Analysis of changed metabolites in HSP can help understand the cellular mechanism, find the novel biomarkers and subsequently design a diagnosis test. In this study, the analysis of samples performed by proton nuclear magnetic resonance spectroscopy (H-1 NMR spectroscopy) to identify the various metabolites, with the aim of finding metabolic profiles and biomarkers related to male infertility. Eighteen de-regulated metabolites were identified in fertile men compared to teratozoospermia patients. These changes illustrate the deficiencies in absorption or metabolism of these metabolites in teratozoospermia. Furthermore, metabolic profiling showed that it is not possible to classify teratozoospermia based on teratozoospermia index (TZI). To the best of our knowledge, this is the first metabolic profiling analysis of HSP described the metabolic features of teratozoospermia in a holistic view. (C) 2019 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Teratozoospermia Male infertility Metabolomics NMR Human seminal plasma myoinositol Chemistry Pharmacology & Pharmacy
Page Range: p. 5
Journal or Publication Title: J Pharm Biomed Anal
Journal Index: ISI
Volume: 178
Identification Number:
ISSN: 0731-7085
Depositing User: مهندس مهدی شریفی

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