Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Possible Targets and Therapies of SARS-C V-2 Infection

(2020) Possible Targets and Therapies of SARS-C V-2 Infection. Mini-Reviews in Medicinal Chemistry. pp. 1900-1907. ISSN 1389-5575

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The global spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes COVID-19 has become a source of grave medical and socioeconomic concern to human society. Since its first appearance in the Wuhan region of China in December 2019, the most effective measures of managing the spread of SARS-CoV-2 infection have been social distancing and lockdown of human activity; the level of which has not been seen in our generations. Effective control of the viral infection and COVID-19 will ultimately depend on the development of either a vaccine or therapeutic agents. This article highlights the progresses made so far in these strategies by assessing key targets associated with the viral replication cycle. The key viral proteins and enzymes that could be targeted by new and repurposed drugs are discussed.

Item Type: Article
Keywords: COVID-19 SARS-CoV-2 infection cycle structural proteins non-structural proteins RNA dependent RNA polymerase proteases helicase nucleosides hepatitis-c potent inhibitors rna-polymerase virus coronavirus protein replication proteases efficacy Pharmacology & Pharmacy
Page Range: pp. 1900-1907
Journal or Publication Title: Mini-Reviews in Medicinal Chemistry
Journal Index: ISI
Volume: 20
Number: 18
Identification Number:
ISSN: 1389-5575
Depositing User: مهندس مهدی شریفی

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