Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Free Radical Scavenging Principles of Salvia reuterana Boiss. Aerial Parts

(2020) Free Radical Scavenging Principles of Salvia reuterana Boiss. Aerial Parts. Iranian Journal of Pharmaceutical Research. pp. 283-290. ISSN 1735-0328

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Salvia reuterana Boiss. is an aromatic perennial plant traditionally used for its anxiolytic and sedative properties. In the present study, various fractions and essential oil of S. reuterana aerial parts were investigated to find its free radical scavenging principles. Hydroalcoholic fraction with IC(5)0 value of 112.6 +/- 3.2 mu g mL(-1) in DPPH assay demonstrated the highest free radical scavenging activity and was selected to further phytochemical investigation. RP-18 and Sephadex LH-20 column chromatography of the hydroalcoholic fraction resulted in the isolation and structural elucidation of four phenolic derivatives, including apigenin-7-O-beta-D-glucopyranoside (1), luteolin-7-O-beta-D-glucopyranoside (2), rosmarinic acid (3), and luteolin (4). Isolated compounds showed potent free radical scavenging activities (5.1-34.2 mu g mL(-1)), compared with BHT (21.30 +/- 1.9 mu g mL(-1)). Twenty four compounds were also identified in GC-MS analysis of the plant essential oil, of which benzyl benzoate (26.64), n-hexyl benzoate (22.99) and n-hexyl isovalerate (6.04) were the main compounds. The results of the present study introduced S. reuterana as a valuable source of natural phenolic antioxidants which can be utilized in prevention of oxidative stress related diseases. Moreover, interesting composition of S. reuterana essential oil, dominated by non-terpenes compounds (76.17) especially aromatic derivatives, make it an appropriate candidate for more detailed studies.

Item Type: Article
Keywords: Salvia reuterana Boiss DPPH Flavonoid Rosmarinic acid Essential oil GC-MS Benzyl benzoate rosmarinic acid caffeic acid antioxidant activity alpha-glucosidase essential oils luteolin l. lamiaceae antibacterial inhibition Pharmacology & Pharmacy
Page Range: pp. 283-290
Journal or Publication Title: Iranian Journal of Pharmaceutical Research
Journal Index: ISI
Volume: 19
Number: 2
Identification Number:
ISSN: 1735-0328
Depositing User: مهندس مهدی شریفی

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