Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

High frequency distribution of heterogeneous vancomycin resistant Enterococcous faecium (VREfm) in Iranian hospitals

(2013) High frequency distribution of heterogeneous vancomycin resistant Enterococcous faecium (VREfm) in Iranian hospitals. Diagnostic Pathology. ISSN 17461596 (ISSN)

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Background: Enterococcus faecium is a multi-resistant nosocomial pathogen causing infection in debilitated patients. Vancomycin-resistant enterococcus faecium (VREfm) are a major concern and increased dramatically worldwide especially in hospitals environment. The current study focused on determining the high prevalence and distribution patterns of antibiotic resistance and also its genetic linkages among various VREfm strains isolated from indoor hospitalized patients in four major Iranian teaching hospitals of Tehran. Methods: The clinical samples were obtained from hospitalized patients during September 2010 to June 2011 from different teaching hospitals of Tehran. Antibiotics Resistance patterns, minimum inhibition concentration (MIC) value for vancomycin, ampicillin, gentamicin and presence of genetic linkage among the isolates were determined by pulsed-field gel electrophoresis (PFGE). Results: Overall, total of 92 (41.4) isolates were identified as E. faecium, 45 (49) were resistant to vancomycin with an MIC50 of ≥128 mg/L. The results showed that simultaneous resistance to teicoplanin, ampicillin, gentamicin, ciprofloxacine, tetracycline and erythromycin were observed the most frequent pattern. All the vancomycin resistant E. faecium isolates carried the vanA gene. intensive care units (ICUs) and Kidney transplantation, are most probably the wards with highest risk of infection by VRE. 17 pulsotypes were also detected by PFGE, most of the related pulsotypes belongs to the same hospitals. Conclusions: This study shows the high alarming prevalence of Enterococcus faecium infection and similar clones of VREfm strains in Iranian hospitals with threatening resistance phenotypes. Virtual slides: The virtual slides for this article can be found here: © 2013 Shokoohizadeh et al.; licensee BioMed Central Ltd.

Item Type: Article
Keywords: E. faecium Hospital and PFGE Vancomycin resistant antiinfective agent antibiotic resistance article cross infection drug effect Enterococcus faecium genetic linkage genetics genotype Gram positive infection hospital subdivisions and components human Iran isolation and purification microbial sensitivity test microbiology multidrug resistance phenotype prevalence pulsed field gel electrophoresis Anti-Bacterial Agents Drug Resistance, Multiple, Bacterial Electrophoresis, Gel, Pulsed-Field Gram-Positive Bacterial Infections Hospital Units Humans Microbial Sensitivity Tests Vancomycin Resistance
Journal or Publication Title: Diagnostic Pathology
Journal Index: Scopus
Volume: 8
Number: 1
Identification Number: 10.1099/jmm.0.036780-0; Feizabadi, M.M., Sayadi, S., Shokrzadeh, L., Parvin, M., Yadegarnia, D., Increase in prevalence of vancomycin resistant isolates of Enterococcous faecium at Labbafinejad hospital (2008) Iran J Clin Infect Di
ISSN: 17461596 (ISSN)
Depositing User: مهندس مهدی شریفی

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