Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Bone scaffold biomimetics based on gelatin hydrogel mineralization

(2013) Bone scaffold biomimetics based on gelatin hydrogel mineralization. Journal of Biomimetics, Biomaterials, and Tissue Engineering. pp. 59-69. ISSN 16621018 (ISSN)

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Apatite phase Calcium and Magnesium Phosphate doped nanocomposite scaffold hasbeen synthesized in physiological environment by gelatin hydrogel double diffusion technique.Several analytical methods, such as X-ray diffraction (XRD), infrared spectroscopy (FTIR), energydispersive spectroscopy (EDS) and scanning electron microscopy (SEM) were applied tocharacterize physicochemical properties of the studied samples.The results showed that nanocomposite scaffolds were porous with three-dimensionallyinterconnected microstructure, pore size ranging from 200 to 300 μm nanocrystalline precipitatedminerals were dispersed evenly among gelatin fibers. A mineral containing amorphous calciumphosphate and brushite precipitate was formed within the gelatin matrix at 4°C. After incubation inSBF solution at 37°C for 7 days, the mineral phase was changed to nanocrystalline hydroxyapatite.It should be well-known that precursor phases inside a scaffold implanted into the bone are equal tobiomimetic adaptation of precursors to hydroxyapatite that is very similar to the bone and has anattentive level of biocompatibility. Therefore, the result confirms the significance of biomimeticcalcium and magnesium phosphate bone tissue scaffolds in developing new biomaterials for boneregeneration. © (2013) Trans Tech Publications, Switzerland.

Item Type: Article
Keywords: Biomimetics Bone Scaffold Mineralization Calcium Phosphates Hydroxyapatite Magnesium Phosphates Tissue Engineering Bone scaffolds Bone tissue scaffolds Calcium and magnesium phosphates Gelatin hydrogels Nanocomposite scaffolds Physicochemical property Physiological environment Biocompatibility Biological materials Bone Calcium phosphate Fourier transform infrared spectroscopy Hydrogels Mineralogy Nanocomposites Phosphate minerals Scanning electron microscopy X ray diffraction Scaffolds (biology)
Page Range: pp. 59-69
Journal or Publication Title: Journal of Biomimetics, Biomaterials, and Tissue Engineering
Journal Index: Scopus
Volume: 17
Identification Number:
ISSN: 16621018 (ISSN)
Depositing User: مهندس مهدی شریفی

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