Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Levothyroxine therapy attenuates anxiety-like states induced by mild chronically of neonatal hypothyroidism in both male and female rats

(2021) Levothyroxine therapy attenuates anxiety-like states induced by mild chronically of neonatal hypothyroidism in both male and female rats. Toxin Reviews. pp. 1518-1525. ISSN 15569543 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Subclinical hypothyroidism tends to be more prevalent due to having a deficiency in iodine intake, which could lead to it. The role of sex differentiation in the susceptibility for anxiety-like behaviors of adult rats with mild neonatal hypothyroidism and then levothyroxine therapy is aimed to be investigated. Data showed that in both genders, reduced social performance and increased anxiety-like behaviors were revealed in a dose-dependent manner to propylthiouracil exposure in hypothyroid groups and levothyroxine therapy reversed the impairment performance and increased anxiety-like in the behavioral tests. Therefore, levothyroxine therapy can also be used as therapeutic methods for adult subject treatment. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Keywords: anxiety gender Hypothyroidism levothyroxine rat
Page Range: pp. 1518-1525
Journal or Publication Title: Toxin Reviews
Journal Index: Scopus
Volume: 40
Number: 4
Identification Number: https://doi.org/10.1080/15569543.2020.1741642
ISSN: 15569543 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9355

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