(2021) Levothyroxine therapy attenuates anxiety-like states induced by mild chronically of neonatal hypothyroidism in both male and female rats. Toxin Reviews. pp. 1518-1525. ISSN 15569543 (ISSN)
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Abstract
Subclinical hypothyroidism tends to be more prevalent due to having a deficiency in iodine intake, which could lead to it. The role of sex differentiation in the susceptibility for anxiety-like behaviors of adult rats with mild neonatal hypothyroidism and then levothyroxine therapy is aimed to be investigated. Data showed that in both genders, reduced social performance and increased anxiety-like behaviors were revealed in a dose-dependent manner to propylthiouracil exposure in hypothyroid groups and levothyroxine therapy reversed the impairment performance and increased anxiety-like in the behavioral tests. Therefore, levothyroxine therapy can also be used as therapeutic methods for adult subject treatment. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Keywords: | anxiety gender Hypothyroidism levothyroxine rat |
| Page Range: | pp. 1518-1525 |
| Journal or Publication Title: | Toxin Reviews |
| Journal Index: | Scopus |
| Volume: | 40 |
| Number: | 4 |
| Identification Number: | https://doi.org/10.1080/15569543.2020.1741642 |
| ISSN: | 15569543 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/9355 |
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