Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (ASQA): A Multicenter Post-marketing Surveillance Study

(2021) Assessment of Treatment Safety and Quality of Life in Patients Receiving Etanercept Biosimilar for Autoimmune Arthritis (ASQA): A Multicenter Post-marketing Surveillance Study. Advances in Therapy. pp. 1290-1300. ISSN 0741-238X

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Abstract

Introduction: Phase IV post-marketing surveillance studies are needed to evaluate the real-world safety and effectiveness of drug products. This study aimed to evaluate the safety and effectiveness of biosimilar etanercept (Altebrel, AryoGen Co., Iran) in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PsA). Methods: In this open-label, multicenter, prospective, observational, post-marketing surveillance study, 583 patients received biosimilar etanercept 25 mg twice weekly or 50 mg once weekly and were followed up to 12 months. The primary objective was to evaluate the safety of biosimilar etanercept by documenting all the adverse events in the case report forms throughout the study period. The secondary objective was to evaluate the effectiveness of biosimilar etanercept in study patients, where longitudinal changes in health assessment questionnaire (HAQ), pain, and disease activity scores were assessed. Results: A total of 583 patients (44.80 +/- 13.09 years of age) were included and followed for an average of 8.12 +/- 3.96 months. Among all patients, 172 (29.50) experienced at least one adverse event, and injection site reaction, abdominal pain, and upper respiratory tract infection were the most common. HAQ scores decreased from 1.32 +/- 0.77 at baseline to 0.81 +/- 0.61 at 12 months in patients with RA/PsA (p < 0.01) and from 0.82 +/- 0.58 at baseline to 0.66 +/- 0.63 at 12 months in patients with AS (p = 0.18). Pain scores decreased from 6.49 +/- 2.41 at baseline to 3.51 +/- 2.39 at 12 months (p < 0.01). Conclusion: The results demonstrated the real-world safety and effectiveness of biosimilar etanercept in patients with RA, PsA, and AS.

Item Type: Article
Keywords: Anti-TNF Ankylosing spondylitis Biologic Biosimilar Etanercept Psoriatic arthritis Rheumatoid arthritis Research & Experimental Medicine Pharmacology & Pharmacy
Page Range: pp. 1290-1300
Journal or Publication Title: Advances in Therapy
Journal Index: ISI
Volume: 38
Number: 2
Identification Number: https://doi.org/10.1007/s12325-020-01611-8
ISSN: 0741-238X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/10010

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