Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression

(2021) Hyaluronic acid-based nanoplatforms for Doxorubicin: A review of stimuli-responsive carriers, co-delivery and resistance suppression. Carbohydrate Polymers. p. 21. ISSN 0144-8617

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Abstract

An important motivation for the use of nanomaterials and nanoarchitectures in cancer therapy emanates from the widespread emergence of drug resistance. Although doxorubicin (DOX) induces cell cycle arrest and DNA damage by suppressing topoisomerase activity, resistance to DOX has severely restricted its anti-cancer potential. Hyaluronic acid (HA) has been extensively utilized for synthesizing nanoparticles as it interacts with CD44 expressed on the surface of cancer cells. Cancer cells can take up HA-modified nanoparticles through receptor mediated endocytosis. Various types of nanostructures such as carbon nanomaterials, lipid nanoparticles and polymeric nanocarriers have been modified with HA to enhance the delivery of DOX to cancer cells. Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance. In the present review, the potential methods and application of HA-modified nanostructures for DOX delivery in anti-cancer therapy are discussed.

Item Type: Article
Keywords: CD44 Doxorubicin Drug resistance Endocytosis Hyaluronic acid Nanodelivery system Theranostic mesoporous silica nanoparticles targeted drug-delivery functionalized graphene oxide human gastric-cancer long noncoding rnas in-vitro evaluation lung-cancer controlled-release chitosan nanoparticles hybrid nanoparticles Chemistry Polymer Science
Page Range: p. 21
Journal or Publication Title: Carbohydrate Polymers
Journal Index: ISI
Volume: 272
Identification Number: https://doi.org/10.1016/j.carbpol.2021.118491
ISSN: 0144-8617
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/10120

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