Abstract

Bumblefoot is a general term for any inflammation or degenerative condition of the avian foot. The infection is usually chronic and responds poorly to antimicrobial therapy or immunization. For study of nanosilver effect on treatment of these lesions, 200 pheasants (Phasianus colchicus) with clinically lameness and footpad inflammation were randomly selected from different farms of pheasants in central of Iran. 90 out of 200 pheasants were affected to grade 3 of bumblefoot with positive S. aureus in blood and ulcer culture. This 90 pheasants divided into 3 groups with 3 replicate. Group1 treated with no antibiotic (as control), group2 treated with systemic piperacillin and group 3 treated with systemic piperacillin with a local spray of one nanosilver (SilvoSept). Results represented, after treatments, blood cultures in groups 1, 2 and 3 were 100, 63.3 and 23.3 positive for Staphylococcus aureus, respectively and ulcer cultures in groups 1, 2 and 3 were 100, 83.3 and 16.6 positive for S. aureus, respectively. The difference between before treatment and after treatment was significant. Also, after treatment, the difference between groups 2 and 3 was significant. The results demonstrate that nanoparticle of Silver can be have antimicrobial effect on S. aureus in vitro and in vivo condition and can be useful for treatment of S. aureus infection in skin and local lesions in birds. It was concluded that systemic piperacillin with local SilvoSept can be effective in control of bumblefoot caused with S. aureus infection in pheasant. © IDOSI Publications, 2012.