Abstract

Objectives Nutritional factors affect the incidence, severity of symptoms and progression of multiple sclerosis (MS). However, the role of specific nutritional factors remains largely unknown in MS. We conducted this hospital-based case-controlled study to investigate the association between dietary intake and risk of MS. Materials & Methods This study was conducted on 93 MS patients and 94 age-matched controls from Oct 2015 to Sep 2016 in Tehran, Iran. MS was diagnosed based on 2010 McDonald criteria and Brain Magnetic Resonance Imaging. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Odds ratio and 95 confidence interval of MS was calculated in different food groups using multiple logistic regression models adjusted for potentially confounding variables and compared between the two groups. Results There was no significant difference between the age (34.62 +/- 9.68 vs. 33.96 +/- 8.75) and BMI (23.96 +/- 4.07 vs. 24.47 +/- 4.07) of MS and control group, respectively. Higher intake of processed meat (OR (95 CI))=(2.07(1.18-3.63) and non-processed meat (1.38(1.13-1.68)) were found in the MS group compared with the control. Conclusion Higher intake of processed meat and non-processed meat was associated with increased risk of MS. Further studies on the probable role of these nutritional factors in the pathogenesis of MS are suggested.