Abstract

Trifluralin is one of herbicide which is widely distributed in the human body after absorption, whose target organs can be adipose tissue, kidney, liver, adrenal gland, skin and blood. In this work, we successfully designed a new platform based on silver nanoparticles (Ag NPs) as signal amplifier and reduced graphene oxide modified by polyethylene imine (rGO-PEI) as polymeric substrate for sensitive detection and determination of Trifluralin in human plasma sample. Therefore, a novel interface based on rGO-PEI-AgNPs were prepared by the full electrochemically method on the surface of glassy carbon electrodes. To characterize surface morphology of electrodes, high-resolution field emission scanning electron microscope and energy dispersive spectroscopy was performed. The obtained results from different pulse voltarnmetry and square wave voltanunetry represent that the proposed platform has a good sensitivity on the detection of Trifluralin in linear range of 1 niM to 1 nM with a low limit of quantification of 1 nM. The results reveal that rGO-PEI-AgNPs as a novel biocompatible interface can provide appropriate, reliable, cost-effective, rapid, and user-friendly diagnostic tool on the detection of Trifluralin in human plasma samples.