Abstract

Emergence and spread of Acinetobacter baumannii infections and resistance to most of the antibiotics are a global concern. Recently, we are facing with the development of multi drug resistance (MDR) A. baumannii. Since the organism causes outbreaks of infection and health care associated, the appropriate antibiotic choice for the treatment is a priority. This study was performance in order to elucidate the antibiotic resistance trends among A. baumannii strains. A total of 120 non-duplicate isolates recovered from patients with burn wounds were subjected to conventional cultural and biochemical tests. For those isolates that were preliminary identified as A. baumannii, multiplex PCR was performed. Antimicrobial susceptibility testing was done by disk diffusion agar and broth microdilution methods. In total, 100 isolates (88.3) were identified as A. baumannii using conventional phenotypic methods with subsequent confirmation by multiplex PCR. The majority of the rates of antibiotic susceptibility in A. baumannii were belonged to colistin, tigecycline, tetracycline, and ampicillin/sulbactam with 99, 81, 71, and 56, respectively. High levels of resistance to beta-lactam antibiotics and cephalosporinswere found in our isolates. Among other isolates, MDR A. baumanniistrains showed the most susceptibility to colistin, tigecycline, ampicillin/sulbactam, tetracycline, and imipenem. Combinations antimicrobial agents and prevention of infections transmission are essential in controlling MDR A. baumannii outbreaks, especially in developing countries such as Iran.