(2018) Silver sulfadiazine nanoethogel for burn healing: characterization and investigation of its in vivo effects. Nanomedicine. pp. 1319-1331. ISSN 1743-5889
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Silver sulfadiazine nanoethogel for burn healingCharacterization and investigation of its in vivo effects.pdf Download (6MB) |
Abstract
Aim: Nanoethosomal formulation containing silver sulfadiazine(SSD) was used to reduce bacterial burden and healing time in burn injuries. Materials & methods: Ethosomal formulations were characterized for their size, zeta-potential, morphology, drug encapsulation efficiency and in vitro release kinetics of SSD. Results: The optimized nanoethosomal suspension with a size of 206.7 +/- 1.18, and zeta-potential value of -67.3 +/- 0.45mV exhibited a high SSD encapsulation efficiency (92.03 +/- 0.79). Results of antimicrobial tests indicated SSD-loaded ethosome formulation led to a significant reduction of colony number. Histopathological results demonstrated a wound contraction rate of 96.83 for the group treated with SSD ethosomal gel while untreated group showed 59.41. Conclusion: The SSD ethogels promotes the therapeutic effect of SSD for burn treatment.
| Item Type: | Article |
|---|---|
| Keywords: | ethogels ethosomes in vivo histopathology second-degree burns silver sulfadiazine topical treatment wound model delivery vitro ethosomes curcumin rat biocompatibility nanoparticles efficacy Biotechnology & Applied Microbiology Science & Technology - Other Topics |
| Divisions: | |
| Page Range: | pp. 1319-1331 |
| Journal or Publication Title: | Nanomedicine |
| Journal Index: | ISI |
| Volume: | 13 |
| Number: | 11 |
| Identification Number: | https://doi.org/10.2217/nnm-2017-0385 |
| ISSN: | 1743-5889 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/3769 |
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