Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

A review on symptoms, treatments protocols, and proteomic profile in sulfur mustard-exposed victims

(2018) A review on symptoms, treatments protocols, and proteomic profile in sulfur mustard-exposed victims. Journal of Cellular Biochemistry. pp. 197-206. ISSN 0730-2312

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Abstract

Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damages to body tissues. Such as DNA damages, oxidative stress, Apoptosis, and inflammation. Sulfur mustard penetrated body organs and induces long term eye, skin, lung, gastrointestinal, urogenital damages and can cause carcinogenic and mutagenic consequences. Currently there is no definitive treatment protocol for SM exposed patients. The goal of treatment is relieving the symptoms with fast healing rate and retrieval of damaged tissues to normal function and appearance in short period of time. Evaluation of proteomics profile in SM-exposed victims has been performed in animal model and human patients. These studies revealed that different protein were involved in the patients with SM damages to skin and lungs. Apolipoprotein A1, type I cytokeratins K14, K16 and K17, S100 calcium-binding protein A8, 1 haptoglobin isoforms, Amyloid A1, albumin, haptoglobin, and keratin isoforms, immunoglobulin kappa chain are defined expressed proteins in the damaged tissues.

Item Type: Article
Keywords: eye lung proteomics treatment skin sulfur mustard chronic pulmonary complications chronic skin-lesions quality-of-life placebo-controlled trial induced cutaneous complications human epidermal-keratinocytes randomized controlled-trial induced chronic pruritus double-blind alkylating agents Biochemistry & Molecular Biology Cell Biology
Divisions:
Page Range: pp. 197-206
Journal or Publication Title: Journal of Cellular Biochemistry
Journal Index: ISI
Volume: 119
Number: 1
Identification Number: https://doi.org/10.1002/jcb.26247
ISSN: 0730-2312
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4066

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