Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

A new prospect in magnetic nanoparticle-based cancer therapy: Taking credit from mathematical tissue-mimicking phantom brain models

(2017) A new prospect in magnetic nanoparticle-based cancer therapy: Taking credit from mathematical tissue-mimicking phantom brain models. Nanomedicine-Nanotechnology Biology and Medicine. pp. 2405-2414. ISSN 1549-9634

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Abstract

Distribution patterns/performance of magnetic nanoparticles (MNPs) was visualized by computer simulation and experimental validation on agarose gel tissue-mimicking phantom (AGTMP) models. The geometry of a complex three-dimensional mathematical phantom model of a cancer tumor was examined by tomography imaging. The capability of mathematical model to predict distribution patterns/performance in AGTMP model was captured. The temperature profile vs. hyperthermia duration was obtained by solving bio-heat equations for four different MNPs distribution patterns and correlated with cell death rate. The outcomes indicated that bio-heat model was able to predict temperature profile throughout the tissue model with a reasonable precision, to be applied for complex tissue geometries. The simulation results on the cancer tumor model shed light on the effectiveness of the studied parameters. (C) 2017 Elsevier Inc. All rights reserved.

Item Type: Article
Keywords: Magnetic nanoparticles Hyperthermia Tissue-mimicking phantoms Mathematical model heating efficiency tumor ablation hyperthermia temperature injury simulation apoptosis strategy cells skin Science & Technology - Other Topics Research & Experimental Medicine
Divisions:
Page Range: pp. 2405-2414
Journal or Publication Title: Nanomedicine-Nanotechnology Biology and Medicine
Journal Index: ISI
Volume: 13
Number: 8
Identification Number: https://doi.org/10.1016/j.nano.2017.07.013
ISSN: 1549-9634
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4163

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