Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Association of 1082g/a estrogen receptor genes polymorphisms with recurrent abortions using as-pcr

(2015) Association of 1082g/a estrogen receptor genes polymorphisms with recurrent abortions using as-pcr. Scientific Journal of Kurdistan University of Medical Sciences. pp. 93-101. ISSN 1560652X (ISSN)

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Abstract

Background and Aim: Abortion is spontaneous termination of pregnancy before the 20th week. Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses. There are several known risk factors associated with recurrent miscarriages, including genetic, endocrine, autoimmune, anatomical. Causes of recurrent miscarriages in 50 of the cases remain unexplained. It has been hypothesized that genetic polymorphism in estrogen receptor genes would be associated with recurrent miscarriages. Material and Materials: This study included 80 patients with a history of three or more consecutive unexplained abortions and 80 women with at least 2 live births without any miscarriage. Then we investigated estrogen receptor gene polymorphism in the participants by allele specific polymerase chain reaction (AS-PCR) method. Results: The frequencies of rs1256149 polymorphisms among the women with recurrent abortions and also the women in the control group were 80 and 62.5 respectively. There was a significant difference in the genotype frequencies between RPL and the control groups (p=0.028). Conclusion: These findings indicated that estrogen receptor polymorphism can be regarded as a genetic marker for recurrent spontaneous abortions. © 2015, Kurdistan University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Estrogen receptor gene Polymorphisms of 1082G/A Recurrent pregnancy loss estrogen receptor allele specific polymerase chain reaction Article controlled study disease association DNA polymorphism female gene frequency genetic association human live birth major clinical study polymerase chain reaction recurrent abortion spontaneous abortion
Divisions:
Page Range: pp. 93-101
Journal or Publication Title: Scientific Journal of Kurdistan University of Medical Sciences
Journal Index: Scopus
Volume: 20
Number: 5
ISSN: 1560652X (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/422

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