Abstract

Despite significant progresses in the development and emergence of new antibiotics, it is still a major problem to treat intracellular bacterial pathogens in human infections. Concentration in specific doses of antibiotics is often dependent on the type of treatment and some drugs may be prescribed in large doses for more efficiency. This is important not only economically, but also may cause localized or side effects in individual patients. On the other hand the emergence of antimicrobial resistance caused that treatment of inner celullar bacteria has not been successfully completed. The use of nanoparticles for drug delivery systems caused to optimize the effectiveness of the treatment process and subsequently better in this kind of infections. polymeric nanoparticles are of particular importance due to biodegradability and biocompatibility. On the other hand, the nanoparticles particularly increase the phagocytic activity and operate as desired in drug delivery systems. Due to great efforts in recent years in the field, there is no doubt that the nanoparticles improve the treatment of intracellular bacterial agents, optimize the chronic infections and minimize their side effects. In this review, applicaions of drug delivery systems are used, leading to effective performance on target bacteria.