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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells

(2017) Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells. Biomedicine & Pharmacotherapy. pp. 719-731. ISSN 0753-3322

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Abstract

Extensive studies have been performed to clarify the processes during which mesenchymal stem cells (MSCs) differentiate into their lineage fates. In vitro differentiation of MSCs into distinct lineages have attracted the focus of a large number of clinical investigations. Although the gene expression profiling during differentiation of MSC toward bone, cartilage, and adipocytes is well established, the master regulators by which MSC fate can be controlled are not entirely determined. During differentiation of MSCs into a special cell fate, epigenetic mechanisms considered as the primary mediators that suppress the irrelevant genes and activate the genes required for a specific cell lineage. This review dedicated to addressing the changes of various epigenetic mechanisms, including DNA methylation, histone modifications, and micro-RNAs during chondrogenic and adipogenic differentiation of MSC. (C) 2017 Elsevier Masson SAS. All rights reserved.

Item Type: Article
Keywords: Epigenetics MSCs Chondrogenic and adipogenic differentiation oligomeric matrix protein dna methylation gene-expression adipocyte differentiation histone deacetylase down-regulation transcription factors promoter regions binding protein ppar-gamma Research & Experimental Medicine Pharmacology & Pharmacy
Divisions:
Page Range: pp. 719-731
Journal or Publication Title: Biomedicine & Pharmacotherapy
Journal Index: ISI
Volume: 89
Identification Number: https://doi.org/10.1016/j.biopha.2017.02.093
ISSN: 0753-3322
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4448

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