(2017) Chelator-free radiolabeling of dextran with Ga-68 for PET studies. Journal of Radioanalytical and Nuclear Chemistry. pp. 1811-1817. ISSN 0236-5731
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Abstract
The possibility of Ga-68-dextran complex formation was analyzed in an HEPES-buffered (pH = 4.5) as well as in an alkaline (pH = 9) solution. The result outlined that the alkaline solution was more efficient to achieve a radiolabeling efficiency of 99 for a 5 mg ml(-1) dextran solution (10 min, 90 degrees C). Ga-68-dextran was stable 88, 71 and 86 after 2 h at storage and toward cysteine solution and human serum, respectively. The highest ROI derived ID g(-1) was found within the lungs, followed by the blood, liver, and bladder. Furthermore, a significant uptake was observed in the cartilage tissue. Ga-68-dextran excreted more by the urinary and less by the biliary pathways.
| Item Type: | Article |
|---|---|
| Keywords: | Dextran Ga-68 PET/CT ROI Biodistribution blood binding spect nanoparticles mechanism agent Chemistry Nuclear Science & Technology |
| Divisions: | |
| Page Range: | pp. 1811-1817 |
| Journal or Publication Title: | Journal of Radioanalytical and Nuclear Chemistry |
| Journal Index: | ISI |
| Volume: | 311 |
| Number: | 3 |
| Identification Number: | https://doi.org/10.1007/s10967-016-5164-z |
| ISSN: | 0236-5731 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/4538 |
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