(2016) The effect of vitamin E on lung pathology in sulfur mustard-exposed guinea pigs. Toxicology and Industrial Health. pp. 1971-1977. ISSN 0748-2337
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Abstract
Pulmonary complications of exposure to sulfur mustard (SM) gas range from no effect or mild symptoms to severe bronchial stenosis. In the present study, the protective effect of vitamin E on the lung inflammation of SM-exposed guinea pigs was examined. Guinea pigs (n = 5 for each group) were exposed to ethanol (control group), 40 mg/m(3) inhaled SM (SME group), SME treated with vitamin E (SME + E), SME treated with dexamethasone (SME + D), and SME treated with both treatments (SME + E + D). Pathological evaluation of the lung was done 14 days postexposure. The epithelial desquamation of trachea and other pathologic changes in the lung of the SME group were significantly higher than those in the control group. Furthermore, the pathological changes of trachea and lung in the SME + E and SME + E + D groups were significantly improved compared with those of SME group. In addition, the pathological changes of trachea and lung of SME + E and SME + E + D animals were significantly less than those of SME + D group.
| Item Type: | Article |
|---|---|
| Keywords: | Lung pathology sulfur mustard vitamin E dexamethasone pulmonary-function tests chemical warfare respiratory symptoms nigella-sativa dexamethasone inhalation gas toxicokinetics responsiveness inflammation Public, Environmental & Occupational Health Toxicology |
| Divisions: | |
| Page Range: | pp. 1971-1977 |
| Journal or Publication Title: | Toxicology and Industrial Health |
| Journal Index: | ISI |
| Volume: | 32 |
| Number: | 12 |
| Identification Number: | https://doi.org/10.1177/0748233715600986 |
| ISSN: | 0748-2337 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/4780 |
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