Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Mindfulness-based Stress Reduction (MBSR) and Its Effects on Psychoimmunological Factors of Chemically Pulmonary Injured Veterans

(2016) Mindfulness-based Stress Reduction (MBSR) and Its Effects on Psychoimmunological Factors of Chemically Pulmonary Injured Veterans. Iranian Journal of Allergy Asthma and Immunology. pp. 476-486. ISSN 1735-1502

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Abstract

Mindfulness-based Stress Reduction (MBSR) is a treatment program for relieving stress and coping with chronic illnesses. In recent three decades, studies have shown that MBSR has a positive effect on physical and psychological dimensions of chronic illnesses. Chemically pulmonary injured veterans have chronic pulmonary and psychological problems due to mustard gas exposure and complications of Iran-Iraq war. These stresses have negative effects on their general health and immune system. To the best of our knowledge, this is the first study conducted on psychoneuroimmunology and MBSR in these patients. Forty male pulmonary injured veterans were randomly divided in two groups with 20 participants (MBSR and wait-list control). Then MBSR group received 8 weekly sessions of intervention. We tested mental health based on general health questionnaire (GHQ)-28 questionnaire, health-related quality of life (based on St. George respiratory questionnaire (SGRQ)) and immunity in MBSR groups; before and after intervention "mixed factorial analyses of variance" test was used for analyzing data fpr each dependent variable and appropriate t-tests were done in The necessary condition. Results showed that mental health and health-related quality of life, in MBSR group compared to wait-list control improved F (1,38)= 26.46, p< 0.001; F (1,38)= 49.52, p< 0.001 respectively significantly. Moreover, a significant increase was reported in the lymphocyte proliferation with phytohemagglutinin (PHA) F (1,38)= 16.24, p< 0.001, and peripheral blood IL-17 F (1,38)= 56.71, p< 0.001 However, lymphocyte (CD4+, CD8+, and NK-cell) percentages were not affected significantly F (1,38)= 2.21, p= 0.14,F (1,38)= 0.90, p= 0.78 and F (1,38)= 1.79, p= 0.18, respectively. This study suggests that MBSR may be a new treatment approach for improving immunity and overall health in chemically pulmonary injured veterans.

Item Type: Article
Keywords: CD4+ CD8+ IL-17 Lymphocyte proliferation Mindfulness Mental health NK-cell Quality of life Veterans quality-of-life randomized controlled-trial psychological distress clinical-trial breast meditation program anxiety therapy immune Allergy Immunology
Divisions:
Page Range: pp. 476-486
Journal or Publication Title: Iranian Journal of Allergy Asthma and Immunology
Journal Index: ISI
Volume: 15
Number: 6
ISSN: 1735-1502
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/4789

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