(2016) Analyzing the effect of MicroRNAs on Hepatogenic differentiation of Mesenchymal stem cells. International Journal of Advanced and Applied Sciences. pp. 69-74. ISSN 2313-626X
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Abstract
This research aims at analyzing the effect of microRNAs on hepatogenic Differentiation of mesenchymal stem cells. According to the results, miR-1246, miR-1290, miR-148a, miR-30a, miR-424 and miR-542-5p were definitely overexpressed during hepatic differentiation of hMSCs. Also the results indicate that ectopic overexpression of miR-122 cannot initiate hepatic differentiation of hMSCs. In other words, hMSCs can be converted into functional hepatocytes only if all the miRs (miR-122, miR-1246, miR-1290, miR-148a, miR-30a, miR-424, and miR-542-5p) are used. (C) 2016 The Authors. Published by IASE.
| Item Type: | Article |
|---|---|
| Keywords: | Hepatogenic Mesenchymal stem cells MicroRNAs hepatic differentiation liver-regeneration hepatocyte proliferation cycle progression overexpression inhibition Science & Technology - Other Topics |
| Divisions: | |
| Page Range: | pp. 69-74 |
| Journal or Publication Title: | International Journal of Advanced and Applied Sciences |
| Journal Index: | ISI |
| Volume: | 3 |
| Number: | 7 |
| Identification Number: | https://doi.org/10.21833/ijaas.2016.07.011 |
| ISSN: | 2313-626X |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/4953 |
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