(2016) DESIGN, SYNTHESIS AND EVALUATION OF NEW AZOLES AS ANTIFUNGAL AGENTS: A MOLECULAR HYBRIDIZATION APPROACH. Pharmaceutical Chemistry Journal. pp. 687-693. ISSN 0091-150X
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DESIGN, SYNTHESIS AND EVALUATION OF NEW AZOLES AS ANTIFUNGAL AGENTS A MOLECULAR HYBRIDIZATION APPROACH.pdf Download (179kB) |
Abstract
Two benzimidazole derivatives and one nitroimidazole derivative were designed using molecular hybridization approach. The designed compounds were synthesized and their in vitro antifungal activities were tested against Candida albicans and Saccharomyces cerevisiae strains. Based on the antifungal activity data, compound 9 containing 2-methyl-5-nitroimidazole moiety proved to be the most potent compound. It was more active than the reference drugs fluconazole and ketoconazole against S. cerevisiae.
| Item Type: | Article |
|---|---|
| Keywords: | benzimidazole nitroimidazole azole antifungal activity in-vitro fungi derivatives Pharmacology & Pharmacy |
| Divisions: | |
| Page Range: | pp. 687-693 |
| Journal or Publication Title: | Pharmaceutical Chemistry Journal |
| Journal Index: | ISI |
| Volume: | 49 |
| Number: | 10 |
| Identification Number: | https://doi.org/10.1007/s11094-016-1354-9 |
| ISSN: | 0091-150X |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/5134 |
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