Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Presence of plus-strand HCV RNA in serum and PBMCs as an indicator for relapse and resistance to IFN therapy in patients infected by HCV

(2012) Presence of plus-strand HCV RNA in serum and PBMCs as an indicator for relapse and resistance to IFN therapy in patients infected by HCV. Future Virology. pp. 323-330. ISSN 1746-0794

[img] Text
Presence of plus-strand HCV RNA in serum and PBMCs as an indicator for relapse and resistance to IFN therapy in patients infected by HCV.pdf

Download (1MB)

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Aim: The aim of our study was to investigate the correlation between the presence of plus-/minus-strand HCV RNA in peripheral blood mononuclear cells (PBMCs) and serum following pegylated IFN/ribavirin therapy with response to therapy in HCV-infected patients. Methods: Forty-three HCV-infected patients who completed 48 weeks of IFN/ribavirin therapy, including 25 sustained virologic responders, 12 resistants and six relapsers, comprised the study population. Plus-/minus-strand HCV RNA was detected by reverse transcription PCR in serum and PBMCs. Results: The frequency of plus-strand HCV RNA was significantly higher in PBMC and serum samples of relapsers and resistants, and this might have important implications in clinical practice and patient management. There was no correlation between presence of plus- and minus-strand HCV RNA and genotypes, except the fact that most of the patients who had plus-strand HCV RNA in PBMCs (60) and in serum (61.53) belonged to genotype la. Conclusion: Presence of plus-strand HCV RNA in PBMCs and serum after termination of therapy is associated with viral relapse and resistance to IFN/ribavirin treatment in HCV-infected patients.

Item Type: Article
Keywords: IFN/RBV therapy PBMC relapser resistant responder serum strand-specific RNA hepatitis-c-virus blood mononuclear-cells peripheral-blood b-virus interferon therapy antiviral therapy negative-strand liver replication genotypes Virology
Divisions:
Page Range: pp. 323-330
Journal or Publication Title: Future Virology
Journal Index: ISI
Volume: 7
Number: 3
Identification Number: https://doi.org/10.2217/fvl.12.9
ISSN: 1746-0794
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6363

Actions (login required)

View Item View Item