Abstract

Objectives: To date, limited data are currently available on posttransplant hyperuricemia in elderly renal transplant patients. Materials and Methods: We conducted a retrospective study on 120 renal transplant patients aged >= 60 years old who received a kidney with at least a minimum time of 1 year after transplant between 2008 and 2011 in Iran. Hyperuricemia was defined if serum uric acid was >= 416.36 mu mol/L in men (7.0 mg/dL), and >= 356.88 mu mol/L in women (6 mg/dL) that persisted for at least 2 consecutive tests. Moderate-to-severe hyperuricemia also was defined as a serum uric acid of >= 475.84 mu mol/L (8.0 mg/dL) in both sexes. Results: The majority of cases were men (66) and only 9 received their grafts from deceased donors. The rate of deceased kidney transplant was higher in normouricemic patients. The prevalence of late posttransplant hyperuricemia was 37.5 of patients (n=45). Moderate-to-severe hyperuricemia was seen in 21 patients (17.5). Although hyperuricemia was commonly observed in women than in men (43 in women vs 32 in men; P = .02), the rate of moderate-to-severe hyperuricemia was similar among both sexes (4.5 vs 4.3; P = .9). Hyperuricemia frequently occurred in patients receiving kidney from a female donor (50 vs 29; P = .005). In univariate analysis, a significant correlation was seen between serum uric acid and serum creatinine (r=0.5, P = .000). On multivariate regression, high serum creatinine was only a risk factor for posttransplant hyperuricemia in elderly kidney transplants (P = .000). Conclusions: Posttransplant hyperuricemia was a quite common among elderly aged kidney recipients. It was correlated with renal allograft impairment.