Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Treatment of Chronic Hepatitis C Infection: Update of the Recommendations from Scientific Leader's Meeting-28th July 2011-Tehran, IR Iran

(2011) Treatment of Chronic Hepatitis C Infection: Update of the Recommendations from Scientific Leader's Meeting-28th July 2011-Tehran, IR Iran. Hepatitis Monthly. pp. 703-713. ISSN 1735-143X

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Abstract

Hepatitis C remains as an important health problem worldwide. Hepatitis C treatment, especially among patients infected with HCV genotype 1 who are considered difficult to treat, is a high priority for health policy-makers. PegInterferon alfa instead of Interferon and ribavirin combination therapy has been accepted as the standard treatment regimen for hepatitis C patients; however, only 50 of patients infected with HCV genotype 1 achieve a sustained virological response. Published data from various clinical trials of protease inhibitors suggest that new therapeutic regimens may increase the chances of a successful response in patients infected with HCV genotype 1. Triple therapy that includes boceprevir has been shown to result in high rates of sustained virological response in both naive and experienced patients with HCV genotype 1 infection. In this review, we have summarized the results obtained with this new regimen and have attempted to provide a guideline for the treatment of patients in Iran, with emphasis on cost and the occurrence of adverse events. (C) 2011 Kowsar M.P.Co. All rights reserved.

Item Type: Article
Keywords: Hepatitis C Therapy Public health Iran human-immunodeficiency-virus rapid virological response liver fibrosis progression natural-history protease inhibitors alpha-interferon plus ribavirin hcv genotypes disease Gastroenterology & Hepatology
Divisions:
Page Range: pp. 703-713
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 11
Number: 9
Identification Number: https://doi.org/10.5812/kowsar.1735143X.769
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6522

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