Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Preliminary report of hepatitis B virus genotype prevalence in Iran

(2006) Preliminary report of hepatitis B virus genotype prevalence in Iran. World Journal of Gastroenterology. pp. 5211-5213. ISSN 1007-9327

[img] Text
Preliminary report of hepatitis B virus genotype prevalence in Iran..pdf

Download (587kB)

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

AIM: To determine the prevalence of hepatitis B virus (HBV) genotypes in Iranian hepatitis B surface antigen (HBsAg) carriers, chronic hepatitis B and cirrhotic patients. METHODS: A total of 109 HBsAg-positive patients were included in this study. HBV genotypes were determined by using INNO-LiPA methodology which is based on the reverse hybridization principle. RESULTS: The distribution of patients with different stages of liver disease was as follows: 95 (86.4) chronic hepatitis, 11 (10) liver cirrhosis, and 3 (2.7) inactive carrier. Of the chronic hepatitis and liver cirrhosis patients, 26.4 were HBeAg-positive while 70 were HBeAg-negative. Genotype D was the only detected type found in all patients. CONCLUSION: Classifying HBV into genotypes has to be cost-effective and clinically relevant. Our study indicates that HBV genotype D prevails in the Mediterranean area, Near and Middle East, and South Asia. Continue efforts for understanding HBV genotype through international co-operation will reveal further virological differences of the genotypes and their clinical relevance. (C) 2006 The WJG Press. All rights reserved.

Item Type: Article
Keywords: hepatitis B virus genotype chronic hepatitis B cirrhosis phylogenetic relatedness molecular epidemiology variability infection sequence carriers Gastroenterology & Hepatology
Divisions:
Page Range: pp. 5211-5213
Journal or Publication Title: World Journal of Gastroenterology
Journal Index: ISI
Volume: 12
Number: 32
ISSN: 1007-9327
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/7223

Actions (login required)

View Item View Item