Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Dose Rate Determination of Gamma Rays Emitted by Thallium-201 and Technetium-99m Using a Modified Horseradish Peroxidase Based Biosensing System

(2010) Dose Rate Determination of Gamma Rays Emitted by Thallium-201 and Technetium-99m Using a Modified Horseradish Peroxidase Based Biosensing System. Journal of the Iranian Chemical Society. pp. 900-907. ISSN 1735-207X

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Abstract

In the presence of low energy gamma emitter radioisotopes of thallium-201 (Tl-201) or technetium-99m (Tc-99m), H2O2 was generated via radiolysis of water. The produced H2O2 was amperometrically determined using an anthraquinone 2-carboxylic acid modified horseradish peroxidase on glassy carbon electrode. In the presence of each radioisotope, the cathodic current produced due to the amperometric detection of H2O2, was designated as biosensor response. At the applied potential of -550 mV (vs. Ag/AgCl), the biosensor showed the sensitivities of 1.937 and 2.278 nA h mu Gy(-1) towards H2O2 produced by Tl-201 and Tc-99m respectively. Finally, the calibration curves for dose rate determination of 201Tl and 99mTc have been presented and the correlations between biosensor response to H2O2 and the gamma emitter dose rates for Tl-201 and Tc-99m are established.

Item Type: Article
Keywords: Thallium-201 Technetium-99m Gamma ray Hydrogen peroxide Horseradish peroxidase Anthraquinone 2-carboxylic acid flow-injection system hydrogen-peroxide accessible lysines water improvement radiation repair damage Chemistry
Divisions:
Page Range: pp. 900-907
Journal or Publication Title: Journal of the Iranian Chemical Society
Journal Index: ISI
Volume: 7
Number: 4
Identification Number: https://doi.org/10.1007/bf03246086
ISSN: 1735-207X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/7367

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