Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Association between Rs 1800561 CD38 gene polymorphism and chronic lymphocytic leukemia risk

(2020) Association between Rs 1800561 CD38 gene polymorphism and chronic lymphocytic leukemia risk. Journal of Mazandaran University of Medical Sciences. pp. 102-108. ISSN 17359279 (ISSN)

[img] Text
Association between Rs 1800561 CD38 gene polymorphism and chronic lymphocytic leukemia risk.pdf

Download (246kB)

Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background and purpose: Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia characterized by the accumulation of seemingly mature type B lymphocytes in peripheral blood and lymphatic organs. One of the main markers used in the diagnosis and prognosis of CLL is the CD38 gene. Polymorphism is considered to be a major genetic source of phenotypic change within a species and may be involved in developing the disease. Here, the study of CD38 gene polymorphism (rs 1800561) was done in terms of incidence and relevance to clinical and laboratory parameters in CLL patients. Materials and methods: In order to confirm the CLL disease, CD5, CD19, and CD23 markers were investigated using immunophenotyping. CD38 gene polymorphism was studied in 70 patients with CLL and 70 healthy cases as control using a specific PCR method of polymorphism (Tetra-ARMS-PCR). Statistical analyses were performed in SPSS V18 applying Pearson Chi-Square test. Results: In the patient group, we observed 97 wild-type genotype (CC), 1.5 heterozygote (CT), and 1.5 homozygote (TT). The present study showed that 98.5 of the control subjects had wild-type (CC) and 1.5 had heterozygote (CT). The frequency of C and T alleles in both patients and control groups was 97.9, 2.1, 99.3, and 0.7, respectively. Conclusion: Based on current study, despite differences in frequency of T and C alleles among patients and healthy individuals, no significant difference was found in the occurrence of this polymorphism and the risk of CLL. © 2020, Mazandaran University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: CD38 gene Chronic lymphocytic leukemia Polymorphism Rs 1800561 CD19 antigen CD23 antigen CD5 antigen allele Article chronic lymphatic leukemia controlled study DNA polymorphism gene gene frequency genetic association genotype heterozygote homozygote human immunophenotyping polymerase chain reaction restriction fragment length polymorphism
Page Range: pp. 102-108
Journal or Publication Title: Journal of Mazandaran University of Medical Sciences
Journal Index: Scopus
Volume: 30
Number: 191
ISSN: 17359279 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8386

Actions (login required)

View Item View Item