Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Overview of Silibinin anti-tumor effects

(2020) Overview of Silibinin anti-tumor effects. Journal of Herbal Medicine. p. 10. ISSN 2210-8033

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Abstract

Silibinin is a major component of Silymarin mixture (Silybum marianum), which has traditionally been used to treat a wide range of liver diseases. Recently, Silibinin and its flavonoid derivatives in several in vitro models have shown a significant inhibitory effect in different types of tumors including skin, breast, lung, colon, bladder, prostate, kidney and liver. The chemo-preventive potentials of this flavonoid are promoted by inducing apoptosis, enhancing tumor suppressor and cell cycle inhibitors, inhibiting growth factors, attenuating proliferative mediators, and having anti-angiogenic properties. In the present review study, a summary of the main molecular mechanisms involved in Silibinin anti-cancer effects, up to date utilities and important clinical trials have been presented. In the near future, the results of these studies will provide a more comprehensive perspective of Silibinin and help to optimize its pharmaceutical properties in cancer chemotherapeutic regimens.

Item Type: Article
Keywords: Apoptosis Milk thistle Silibinin Silymarin Tumor cell-cycle arrest causes caspases activation carcinoma a431 cells prostate-cancer signaling pathways inhibits proliferation molecular-mechanisms ceramide metabolism mmp-9 expression milk thistle Integrative & Complementary Medicine
Page Range: p. 10
Journal or Publication Title: Journal of Herbal Medicine
Journal Index: ISI
Volume: 23
Identification Number: https://doi.org/10.1016/j.hermed.2020.100375
ISSN: 2210-8033
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8567

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