(2020) Adipose-derived mesenchymal stem cells ameliorate lung epithelial injury through mitigating of oxidative stress in mustard lung. Regenerative Medicine. pp. 1861-1876. ISSN 1746-0751
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Abstract
Aim:We investigated potential efficacy of autologous adipose-derived mesenchymal stem cell (MSC) on oxidative stress (OS) and airway remodeling in patients with chronic mustard lung.Patients & methods:Ten patients received 100 x 10(6)cells every 20 days for 4 injections over a 2-month period.Results:A gradual improvement was observed for 6 min walk test scores, pulmonary function tests and respiratory quality after MSCs therapy. A significant decrease was found for the mean levels of Mucin-1 protein (KL-6; p = 0.022) and Clara cell protein 16 (CC16; p = 0.005). Antioxidants had a tendency to be higher after each injection.Conclusion:Our findings revealed that MSCs therapy can be safely used for improvement of lung injury and regeneration in these patients without adverse effects.
| Item Type: | Article |
|---|---|
| Keywords: | airway remodeling antioxidants lung regeneration mesenchymal stem cells mustard lung oxidative stress sulfur mustard antioxidant defense lipid-peroxidation exposure overexpression complications consequences inflammation glutathione expression Cell Biology Engineering |
| Page Range: | pp. 1861-1876 |
| Journal or Publication Title: | Regenerative Medicine |
| Journal Index: | ISI |
| Volume: | 15 |
| Number: | 7 |
| Identification Number: | https://doi.org/10.2217/rme-2020-0051 |
| ISSN: | 1746-0751 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/8680 |
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