Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Evaluation of physical, mechanical and biological properties of beta-tri-calcium phosphate/Poly-3-hydroxybutyrate nano composite scaffold for bone tissue engineering application

(2020) Evaluation of physical, mechanical and biological properties of beta-tri-calcium phosphate/Poly-3-hydroxybutyrate nano composite scaffold for bone tissue engineering application. Materials Technology. p. 13. ISSN 1066-7857

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Abstract

Design of a scaffold with convenient mechanical properties to emulate bone structure is a major challenge for bone tissue engineers. In this study, porous ceramic scaffolds containing various weight fractions of nano beta-tricalcium phosphate (n beta-TCP) (with a particle size of about 50-70 nm) were prepared by the replication method. Synthesised scaffolds were then coated with poly(3-hydroxybutyrate) (PHB) for 30 and 60 sec. According to the morphological and mechanical tests, it was determined that synthesised scaffold containing 50 wt. of n beta-TCP with a coating time of 30 sec showed desirable properties in bone tissue engineering. The bioactivity of this scaffold indicated that the bone-like apatite layers were well formed on the nanocomposite scaffold. Cell culture study showed a significant increase in cell proliferation between the coated, uncoated and control sample after 5 days of cell culturing. The results confirm that this nanocomposite scaffold has good potential for bone tissue engineering applications.

Item Type: Article
Keywords: Nano-beta-tricalcium phosphate (n beta-TCP) poly-3-hydroxybutyrate (PHB) scaffold tissue engineering phosphate scaffolds hydroxyapatite biomaterials regeneration bioactivity kinetics behavior fracture design Materials Science
Page Range: p. 13
Journal or Publication Title: Materials Technology
Journal Index: ISI
Identification Number: https://doi.org/10.1080/10667857.2020.1747806
ISSN: 1066-7857
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8868

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