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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Screening for amyloid deposition by subcutaneous fat tissue aspiration technique in rheumatoid arthritic patients and investigating its clinical significance in Iran

(2007) Screening for amyloid deposition by subcutaneous fat tissue aspiration technique in rheumatoid arthritic patients and investigating its clinical significance in Iran. APLAR Journal of Rheumatology. pp. 125-129. ISSN 02190494 (ISSN)

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Abstract

Aim: This study examined the frequency of secondary amyloidosis in Iranian patients with rheumatoid arthritis (RA) in order to determine its clinical significance. Methods: A total of 220 RA patients (167 female, 53 male), with minimum disease duration of 5 years, were included in this prospective study over a period of about 2 years. Abdominal subcutaneous fat-pad aspiration (ASFA) method was used in obtaining specimens from all subjects. All of the specimens were examined for apple-green birefringence under polarized light microscope. Amyloid deposits were graded from 1+ to 3+. Clinical, radiological, and laboratory characteristics of the patients were assessed and recorded. Results: Amyloid deposition was detected in 11 (5) of the fat smears stained with Congo red stain. All of the samples had minimal (1+) amyloid deposits. In this study, amyloid-positive cases showed clinically significant symptoms; six of the patients (55) presented with proteinuria, and seven other cases (64) presented with severe constipation. Conclusion: Abdominal fat amyloid deposition was found to be uncommon in adult Iranian RA patients. In up to half of the patients the deposits were subclinical. A longer follow-up and larger multicentric collaborative study is needed to determine the significance of subclinical amyloid deposits. © 2007 Asia Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty Ltd.

Item Type: Article
Keywords: Congo red staining Rheumatoid arthritis (RA) Secondary amyloidosis (SA) congo red abdominal subcutaneous fat adult aged amyloidosis article aspiration biopsy birefringence clinical assessment clinical study constipation controlled study disease duration female follow up human Iran major clinical study male medical record priority journal protein analysis proteinuria rheumatoid arthritis symptomatology
Divisions:
Page Range: pp. 125-129
Journal or Publication Title: APLAR Journal of Rheumatology
Journal Index: Scopus
Volume: 10
Number: 2
Identification Number: https://doi.org/10.1111/j.1479-8077.2007.00273.x
ISSN: 02190494 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/901

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