Abstract

A cross-sectional study was carried out at the endoscopy unit of Bagqiyatollah University of Tehran. From February 2004 to June 2006, 305 consecutive dyspeptic patients were evaluated. With regard to standard methods, biopsies were taken and cultured. For each isolates Minimum Inhibitory Concentrations (MIC) for Metronidazole (MTZ), Amoxicillin (AMX), Tetracycline (TC) and Ciprofloxacin (CIP) were determined by Epsilometer test. Considering standard resistance breakpoints, our data was analyzed and resistance rates were reported. One hundred forty nine patients, had a positive culture. The resistance rate in H.P. isolates were as follows: MTZ (60.4), CIP (40.3), AMX (15.4) and TC (10.7). 82.6 of isolates were resistance to at least one drug. In resistance group: 56, 39 and 5 of isolates displayed single, dual and triple drug resistant pattern, respectively. In the different age groups or sex groups there was no difference (p>0.1) in the antibiotics resistance rates except for TC (p = 0.01) which was more common in older groups (17.1 versus 4.1). In present study we confronted with markedly high rate of resistance to metronidazole and ciprofloxacin, furthermore other antibiotics displayed significant resistance rate and there was some level of overlap between resistances to these drugs. It seems that in Iran HP eradication is more difficult and demand more concern. © 2007 Academic Journals Inc.