Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effects of ultra-low doses of nicotine on the expression of morphine-induced conditioned place preference in mice

(2006) Effects of ultra-low doses of nicotine on the expression of morphine-induced conditioned place preference in mice. Behavioural Pharmacology. pp. 629-635. ISSN 09558810 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

In the present study, the effects of acute administration of nicotine, as well as nicotinic and muscarinic acetylcholine receptor antagonists, on the expression of morphine-induced conditioned place preference, have been investigated in male Swiss-Webster mice. Animals received different doses of morphine 5 days after surgical cannulation in the lateral ventricle. Subcutaneous injections of morphine (2-5 mg/kg) in mouse produced place preference in a dose-dependent manner. Furthermore, both intraperitoneal (0.0006-0.1 mg/kg) and intracerebroventricular (0.007-25 ng) nicotine administration significantly reduced the expression of morphine-induced place preference, in a dose-dependent manner. Nicotine, however, was effective over narrow ultra-low dose ranges (0.0012, 0.0025, 0.005 and 0.01 mg/kg; intraperitoneal) and (0.03, 0.1, 0.3 and 0.6 ng/mouse; intracerebroventricular). In addition, locomotor activity was reduced when higher doses of nicotine both intraperitoneal (0.02, 0.03 and 0.1 mg/kg) and intracerebroventricular (10 and 24 ng/mouse) were used. Nicotine alone, however, did not cause motivational effects. Intracerebroventricular injection of hexamethonium (0.03, 0.1 and 0.3 μg/mouse; 10 min before nicotine) diminished the effects of nicotine on morphine-induced conditioned place preference. This effect could neither be obtained by intraperitoneal administration of hexamethonium (1, 5 and 10 mg/kg; 30 min before nicotine), nor be reproduced after either intracerebroventricular or intraperitoneal injection of atropine (a muscarinic receptor antagonist). The antagonists, themselves, did not show any motivational effects when used alone and were unable to affect the expression of morphine-induced conditioned place preference. It appears that ultra-low doses of nicotine can reduce the expression of morphine-induced place preference, and that central nicotinic acetylcholine receptors play a role in this regard. © 2006 Lippincott Williams & Wilkins, Inc.

Item Type: Article
Keywords: Atropine Conditioned place preference Hexamethonium Morphine Mouse Nicotine Ultra-low doses muscarinic receptor blocking agent naloxone nicotinic receptor nicotinic receptor blocking agent animal experiment animal tissue article aversion controlled study dose response drug antagonism drug megadose locomotion low drug dose male memory motivation nonhuman place preference receptor intrinsic activity reward Animals Conditioning, Operant Dose-Response Relationship, Drug Injections, Intraventricular Injections, Subcutaneous Mice Motor Activity Narcotics Nicotinic Agonists Nicotinic Antagonists Receptors, Nicotinic Reinforcement (Psychology)
Divisions:
Page Range: pp. 629-635
Journal or Publication Title: Behavioural Pharmacology
Journal Index: Scopus
Volume: 17
Number: 7
Identification Number: https://doi.org/10.1097/FBP.0b013e3280102d68
ISSN: 09558810 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/927

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