(2021) HIV-Tuberculous Meningitis Co-Infection: A Systematic Review and Meta-Analysis. Current Pharmaceutical Biotechnology. pp. 960-968. ISSN 1389-2010
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Abstract
Human Immunodeficiency Virus (HIV)-infected persons are at a higher risk of developing Tuberculous Meningitis (TBM). We aimed to estimate the prevalence of TBM-HIV co-infection. We systematically searched Pubmed/Medline, Embase and Cochrane library databases from January 1, 2000, to January 31, 2017, to find relevant studies. We employed the random-effects meta-analysis model to estimate the pooled prevalence of TBM-HIV co-infection. Twenty-six eligible studies showed the prevalence of HIV in TBM patients. In the pooled analyses, the prevalence of HIV was 30 (95 CI: 12-47) in patients with confirmed TBM, and 12.1 (95 CI: 7.3-19.2) in patients with suspected TBM. This study shows a high prevalence of TBM-HIV co-infection. Establishing proper diagnostic criteria and preventive measures for TBM infections could assist in the prevention and management of TBM infection, particularly TBM-HIV co-infection.
| Item Type: | Article |
|---|---|
| Keywords: | Meta-analysis HIV meningitis Mycobacterium tuberculosis TBM prevention human-immunodeficiency-virus polymerase-chain-reaction cerebrospinal-fluid rapid diagnosis adults amplification accuracy mtb/rif tool pcr Biochemistry & Molecular Biology Pharmacology & Pharmacy |
| Page Range: | pp. 960-968 |
| Journal or Publication Title: | Current Pharmaceutical Biotechnology |
| Journal Index: | ISI |
| Volume: | 22 |
| Number: | 7 |
| Identification Number: | https://doi.org/10.2174/1389201021666200730143906 |
| ISSN: | 1389-2010 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/9855 |
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