(2021) Designing of various biosensor devices for determination of apoptosis: A comprehensive review. Biochemical and Biophysical Research Communications. pp. 42-62. ISSN 0006-291X
Full text not available from this repository.
Abstract
Apoptosis is a type of cell death caused by the occurrence of both pathological and physiological conditions triggered by ligation of death receptors outside the cell or triggered by DNA damage and/or cytoskeleton disruption. Timely monitoring of apoptosis can effectively help early diagnosis of related diseases and continuous assessment of the effectiveness of drugs. Detecting caspases, a protease family closely related to cellular apoptosis, and its identification as markers of apoptosis is a popular procedure. Biosensors are used for early diagnosis and play a very important role in preventing disease progression in various body sections. Recently, there has been a widespread increase in the desire to use materials made of paper (e.g. nitrocellulose membrane) for Point-of-Care (POC) testing systems since paper and paper-like materials are cheap, abundant and degradable. Microfluidic paper-based analytical devices (tPADs) are highly promising as they are cost-effective, easy to use, fast, precise and sustainable over time and under different environmental conditions. In this review, we focused our efforts on compiling the different approaches on identifying apoptosis pathway while giving brief information about apoptosis and biosensors. This review includes recent advantages in biosensing techniques to simply determine what happened in the cell life and which direction it would continue. As a conclusion, we believed that the review may help to researchers to compare/update the knowledge about diagnosis of the apoptosis pathway while reminding the basic definitions about the apoptosis and biosensor technologies. (C) 2021 Elsevier Inc. All rights reserved.
Item Type: | Article |
---|---|
Keywords: | Apoptosis Caspases Biosensors Bioreceptors Paper-based biosensors electrochemical biosensors ultrasensitive detection real-time paper cells quantification platform assay Biochemistry & Molecular Biology Biophysics |
Page Range: | pp. 42-62 |
Journal or Publication Title: | Biochemical and Biophysical Research Communications |
Journal Index: | ISI |
Volume: | 578 |
Identification Number: | https://doi.org/10.1016/j.bbrc.2021.08.089 |
ISSN: | 0006-291X |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.bmsu.ac.ir/id/eprint/9921 |
Actions (login required)
View Item |