Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Herbal Drugs and Natural Products in the light of Nanotechnology and Nanomedicine for Developing Drug Formulations

(2021) Herbal Drugs and Natural Products in the light of Nanotechnology and Nanomedicine for Developing Drug Formulations. Mini-Reviews in Medicinal Chemistry. pp. 302-313. ISSN 1389-5575

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Abstract

Natural products and medicinal plants have played a vital role in providing healthcare and ensuring well-being for many civilizations since antiquity. It is estimated that around 50 of drugs in the market have a natural product origin especially medicinal plants and herbal drugs, animals, fungi, and marine organisms. Some of these biologically active constituents of extracts have low absorption and distribution which, as a result, lead to loss of bioavailability and efficacy and might hamper their applications in the clinic. To overcome these impediments for the formulation of herbal drugs, food supplements, and essential oils, several nanomedical approaches such as liposomes, microemulsions, polymeric nanoparticles, solid lipid nanoparticles (SLN5), liquid crystal systems (LC), and precursor systems for liquid crystals (PSLCs) have been proposed. Nanoparticles have been used to modify and ameliorate the pharmacokinctic and pharmacodynamic properties of different drugs, thus incorporating biotechnological systems may be useful to enhance the bioavailability and bioactivity of herbal drug formulations. Consequently, essential for any natural compounds is the extent of its absorption after being ingested and its ability to be distributed in various tissues or organs of the body. The present review article aims to give an overview of the recent advancements in developing herbal drug formulations based on nanoparticle technologies.

Item Type: Article
Keywords: Bioavailability bioactivity nanomedicine phytomedicine drug delivery natural products solid lipid nanoparticles improved oral bioavailability delivery systems in-vitro antiinflammatory activity plga nanoparticles topical delivery curcumin oil microemulsions Pharmacology & Pharmacy
Page Range: pp. 302-313
Journal or Publication Title: Mini-Reviews in Medicinal Chemistry
Journal Index: ISI
Volume: 21
Number: 3
Identification Number: https://doi.org/10.2174/1389557520666200916143240
ISSN: 1389-5575
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9956

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